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Peptide knowledge hub
An index of published studies and press coverage about research peptides. The work is other people's. Listing it here is not a claim about the products sold on this site, and it is not an endorsement.
Entries are collected automatically from PubMed and from publisher feeds, by search query and date, before their results are known. Null and negative findings are listed alongside the rest. The one-line description under each entry is written by a language model from the paper's abstract: it describes how a study was run, not what it found.
This site supplies research compounds for laboratory use. Confirm the following to continue.
Eighteen studies arrived this period, with the bulk clustering on two compounds. Ten papers examined MOTS-c, a peptide encoded by mitochondrial DNA, across mice and rats. Researchers gave it to animals with radiation-damaged lungs, oxygen-damaged newborn hearts and lungs, simulated high-altitude exposure, diabetes, muscle wasting from tumours, atrial fibrillation, and skin-flap surgery, measuring inflammation, scarring, heart function, blood flow, and tissue survival. One paper also tested it against an abdominal MRSA infection in mice, and another looked at how it affects muscle mitochondria in healthy mice.
Three papers covered BPC-157, all in rats. Two looked at tissue repair: one on surgically cut Achilles tendons given BPC-157, TB-500, or both for four weeks, and one on lower-limb injuries from restricted blood flow. The third examined rats that had one adrenal gland removed, measuring blood pressure and organ damage after the peptide was given by mouth.
Two papers covered
11 matching records
Mice with an abdominal MRSA infection were given MOTS-c, a peptide encoded by mitochondrial DNA, and the researchers compared how the infection progressed in treated and untreated animals.
Rice MC et al. · eLife
View on PubMed(opens in a new tab)Newborn mice exposed to high oxygen were given MOTS-c, and the paper reports that their hearts showed less thickening, scarring, and loss of function than hearts of mice not given the compound.
Li SH et al. · Life sciences
View on PubMed(opens in a new tab)Rats made diabetic with a high-fat diet and a drug that damages the pancreas were given MOTS-c, and the researchers measured their fasting blood sugar, inflammation markers in the blood, and stained heart tissue for signs of inflammatory activity.
Mills AR et al. · Experimental physiology
View on PubMed(opens in a new tab)Mice exposed to radiation that damages the lungs were given daily injections of an engineered peptide called R13A-MOTS-c for two weeks, and the researchers measured inflammation, oxidative damage, and mitochondrial function in their lung tissue.
Zhang YL et al. · Redox biology
View on PubMed(opens in a new tab)Rats with surgically created ischemic skin flaps were given MOTS-c, and the researchers measured blood flow, tissue survival, and cell-level changes in the flaps.
Shi J et al. · Autophagy
View on PubMed(opens in a new tab)Mice with angiotensin II-induced atrial fibrillation were given HNG or MOTS-c, and the researchers measured how often the heart rhythm disturbance could be triggered, along with signs of scarring and damage in the heart tissue.
Liao Y et al. · Biomedicines
View on PubMed(opens in a new tab)Mice exposed to simulated high altitude for 10 days were given MOTS-c during a 10-day return to low altitude, and their heart function was measured to see if the peptide helped reverse damage.
Feng Z et al. · Free radical biology & medicine
View on PubMed(opens in a new tab)Newborn mice with lung damage from breathing 70% oxygen were given MOTS-c, a small peptide, and the paper reports less lung scarring and better blood vessel growth in the treated mice.
Chen D et al. · European journal of pharmacology
View on PubMed(opens in a new tab){ "summary": "Mice with normal muscle function were given MOTS-c, and their muscle mitochondria were measured for energy production and oxidative stress, showing improved efficiency and less damage.", "explanation": "Two strains of genetically modified mice were given MOTS-c, a peptide derived from mitochondrial DNA, to study its effect on muscle mitochondria, the parts of cells that produce energy. The researchers measured how well the mitochondria generated energy, how much reactive oxygen species (harmful molecules) they released, and how much protein damage occurred. They found that MOTS-c improved mitochondrial energy performance and reduced oxidative stress, but these effects depended on two specific proteins, PGC-1α and AMPK, which act as regulators in the cell. The improvements happened without increasing the amount of mitochondrial proteins, suggesting the mitochondria themselves became more efficient rather than more numerous. The paper also reports that in humans, exercise did not change the level of MOTS-c in blood flowing out of the leg, indicating that muscle may not be the source of circulating MOTS-c during exercise."
Gudiksen A et al. · Free radical biology & medicine
View on PubMed(opens in a new tab)Mice with sepsis caused by an LPS injection were given MOTS-c before the injection, and the researchers measured survival, brain tissue damage, inflammation, and blood-brain barrier leakage.
Bai Y et al. · The International journal of neuroscience
View on PubMed(opens in a new tab)Mice carrying a tumour that causes muscle wasting were injected with MOTS-c twice a day, and the researchers weighed the animals daily and then measured their leg muscle mass against that of an untreated group.
Jamnick NA et al. · Frontiers in medicine
View on PubMed(opens in a new tab)Every compound this store lists, with what the index holds for it. A count is how many records this index has collected, not a measure of how well supported a compound is.
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Rat studies; none here is marked as human.
newest 2026
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Mouse studies, plus 2 that name no species; none here is marked as human.
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Rat study; none here is marked as human.
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11 records
Mouse and rat studies, plus 9 that name no species; none here is marked as human.
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Currently filtering the index
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No record here names the species studied.
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