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Shi J et al. · Autophagy ·
Rats with a skin flap that had its blood supply cut off, causing ischemia, were given MOTS-c injections. The study used multiple groups of rats, though the exact number is not stated in the abstract. The researchers measured blood flow in the flaps using laser imaging and Doppler analysis, and looked at tissue samples under a microscope to see how much of the flap survived and how well new blood vessels formed. They also tested for specific proteins involved in cell death, recycling of damaged cell parts, and the breakdown of lysosomes, which are the cell's waste disposal sacs. The paper reports that rats given MOTS-c had better blood flow, more surviving flap tissue, and less damage to lysosomes compared to untreated rats, and it identifies a specific signaling pathway involving an enzyme called PLA2G4A that MOTS-c appears to block.
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