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Rice MC et al. · eLife ·
The researchers studied MOTS-c, a small peptide that is made from instructions in the mitochondria, the energy-producing parts of cells, rather than from the main nuclear genome. They first tested it in lab dishes against two bacteria, E. coli and MRSA, and found it killed them by poking holes in their outer membranes. Then they gave MOTS-c to mice with a severe abdominal infection caused by MRSA, and the paper reports that the peptide completely wiped out the infection in those mice. The researchers also grew human immune cells called monocytes in the lab and found that adding MOTS-c while they matured changed them into a type of macrophage that was better at swallowing and clearing bacteria. The paper concludes that MOTS-c is a newly discovered immune defense molecule, but it does not claim that it is a treatment for any human disease.
Compounds