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Grunstein RR et al. · The New England journal of medicine ·
Two trials enrolled adults with moderate-to-severe obstructive sleep apnea and a body-mass index of at least 27. One trial took people without type 2 diabetes and the other took people with it; 243 people were assigned in the first and 448 in the second. Participants were split into groups given GLP-3 R or placebo, and treatment ran for 80 weeks. The main measurement was the apnea-hypopnea index, the average number of apneas and hypopneas per hour of sleep, and body weight was also tracked.
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